Direct fluorescence visualization of clinically occult high‐risk oral premalignant disease using a simple hand‐held device
- 18 September 2006
- journal article
- case report
- Published by Wiley in Head & Neck
- Vol. 29 (1), 71-76
- https://doi.org/10.1002/hed.20468
Abstract
Background A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method to identify such occult change is needed. Methods Patients in the Oral Dysplasia Clinics at British Columbia are currently being examined with a simple hand‐held device that permits the direct visualization of alterations to autofluorescence in the oral cavity. Tissue showing loss of autofluorescence is biopsied. Results We present 3 representative cases in which occult lesions were identified with fluorescence visualization during longitudinal follow‐up, resulting in the diagnosis of a primary dysplasia in case 1, a second primary cancer in case 2, and cancer recurrence in case 3. Conclusions This is the first report of the diagnosis of occult oral disease using a simple noninvasive device. These early examples indicate the potential value of this technology to guide the management of patients with oral lesions, facilitating the detection of high‐risk changes not apparent with white‐light visualization. © 2006 Wiley Periodicals, Inc. Head Neck, 2006Keywords
This publication has 18 references indexed in Scilit:
- Optimal Excitation Wavelengths for In Vivo Detection of Oral Neoplasia Using Fluorescence Spectroscopy ¶Photochemistry and Photobiology, 2007
- Simple device for the direct visualization of oral-cavity tissue fluorescenceJournal of Biomedical Optics, 2006
- The status of in vivo autofluorescence spectroscopy and imaging for oral oncologyOral Oncology, 2005
- Genetically Altered Fields as Origin of Locally Recurrent Head and Neck CancerClinical Cancer Research, 2004
- Vision enhancement system for detection of oral cavity neoplasia based on autofluorescenceHead & Neck, 2004
- Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinomaCancer, 2003
- Characterization of autofluorescence in oral squamous cell carcinomaOral Oncology, 2003
- QUANTITATIVE OPTICAL SPECTROSCOPY FOR TISSUE DIAGNOSISAnnual Review of Physical Chemistry, 1996
- In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence.Proceedings of the National Academy of Sciences of the United States of America, 1994
- Observations on the fluorescent tongue pattern and its relation to the deficiency stateOral Surgery, Oral Medicine, Oral Pathology, 1953