Lithium alters the stereoselectivity of monoamine oxidase in rat brain
- 1 October 1989
- journal article
- Published by Springer Science and Business Media LLC in Journal of Neural Transmission
- Vol. 76 (3), 205-210
- https://doi.org/10.1007/bf01260505
Abstract
The effects of lithium on monoamine oxidase (MAO) in rat brain were studied in the presence of each enantiomer of tranylcypromine [(+)- and (−)-TCP]. The (+)-enantiomer was 25 times more potent than its antipode as MAO inhibitor. Lithium enhanced the inhibitory effect of (−)-TCP on MAO, but it did not affect actions of the (+)-enantiomer. Moreover, lithium influenced the stereo selective index for MAO, which suggests that lithium altered conformational features of the enzyme.Keywords
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