Clinical and biochemical effects of a combination botanical product (ClearGuard™) for allergy: a pilot randomized double-blind placebo-controlled trial
Open Access
- 14 July 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nutrition Journal
- Vol. 7 (1), 20
- https://doi.org/10.1186/1475-2891-7-20
Abstract
Botanical products are frequently used for treatment of nasal allergy. Three of these substances, Cinnamomum zeylanicum, Malpighia glabra, and Bidens pilosa, have been shown to have a number of anti-allergic properties in-vitro. The current study was conducted to determine the effects of these combined ingredients upon the nasal response to allergen challenge in patients with seasonal allergic rhinitis. Twenty subjects were randomized to receive the combination botanical product, (CBP) 2 tablets three times a day, loratadine, 10 mg once a day in the morning, or placebo, using a randomized, double-blinded crossover design. Following 2 days of each treatment and during the third day of treatment, subjects underwent a nasal allergen challenge (NAC), in which nasal symptoms were assessed after each challenge dose and every 2 hours for 8 hours. Nasal lavage fluid was assessed for tryptase, prostaglandin D2, and leukotriene E4 concentrations and inflammatory cells. Loratadine significantly reduced the total nasal symptom score during the NAC compared with placebo (P = 0.04) while the CBP did not. During the 8 hour period following NAC, loratadine and the CBP both reduced NSS compared with placebo (P = 0.034 and P = 0.029, respectively). Analysis of nasal lavage fluid demonstrated that the CBP prevented the increase in prostaglandin D2 release following NAC, while neither loratadine nor placebo had this effect. None of the treatments significantly affected tryptase or leukotriene E4 release or inflammatory cell infiltration. The CBP significantly reduced NSS during the 8 hours following NAC and marginally inhibited the release of prostaglandin D2 into nasal lavage fluid, suggesting potential clinical utility in patients with allergic rhinitis.Keywords
This publication has 23 references indexed in Scilit:
- Johanniskraut – Beiträge der Inhaltsstoffe zu Wirkmechanismen und WirksamkeitWiener Medizinische Wochenschrift, 2007
- Revisiting the ancient concept of botanical therapeuticsNature Chemical Biology, 2007
- Ethyl caffeate suppresses NF‐κB activation and its downstream inflammatory mediators, iNOS, COX‐2, and PGE2in vitro or in mouse skinBritish Journal of Pharmacology, 2005
- Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medicationJournal of Allergy and Clinical Immunology, 2005
- Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitisAnnals of Allergy, Asthma & Immunology, 2004
- Pathophysiology of human basophils and mast cells in allergic disordersClinical Immunology and Immunopathology, 1989
- Mucosal mast cells: III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cellsJournal of Allergy and Clinical Immunology, 1984
- Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenaseBiochemical and Biophysical Research Communications, 1983
- Local Effects of Synthetic Leukotrienes (LTC4, LTD4, and LTB4) in Human SkinJournal of Investigative Dermatology, 1983
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). I. Anti-allergic action.The Japanese Journal of Pharmacology, 1982