A New Modality for Cancer Treatment—Nanoparticle Mediated Microwave Induced Photodynamic Therapy
- 1 October 2016
- journal article
- research article
- Published by American Scientific Publishers in Journal of Biomedical Nanotechnology
- Vol. 12 (10), 1835-1851
- https://doi.org/10.1166/jbn.2016.2322
Abstract
Photodynamic therapy (PDT) has attracted ever-growing attention as a promising modality for cancer treatment. However, due to poor tissue penetration by light, photodynamic therapy has rarely been used for deeply situated tumors. This problem can be solved if photosensitizers are activated by microwaves (MW) that are able to penetrate deeply into tissues. Here, for the first time, we report microwave-induced photodynamic therapy and exploit copper cysteamine nanoparticles as a new type of photosensitizer that can be activated by microwaves to produce singlet oxygen for cancer treatment. Both in vitro and in vivo studies on a rat osteosarcoma cell line (UMR 106-01) have shown significant cell destruction using copper cysteamine (Cu-Cy) under microwave activation. The heating effects and the release of copper ions from Cu-Cy upon MW stimulation are the main mechanisms for the generation of reactive oxygen species that are lethal bullets for cancer destruction. The copper cysteamine nanoparticle-based microwave-induced photodynamic therapy opens a new door for treating cancer and other diseases.Keywords
This publication has 34 references indexed in Scilit:
- Reactive Oxygen Species Formation and Apoptosis in Human Peripheral Blood Mononuclear Cell Induced by 900 MHz Mobile Phone RadiationOxidative Medicine and Cellular Longevity, 2012
- Redox Reactions of the α-Synuclein−Cu2+ Complex and Their Effects on Neuronal Cell ViabilityBiochemistry, 2010
- Microwave Tumor Ablation: Mechanism of Action, Clinical Results, and DevicesJournal of Vascular and Interventional Radiology, 2010
- Reactive oxygen species levels and DNA fragmentation on astrocytes in primary culture after acute exposure to low intensity microwave electromagnetic fieldNeuroscience Letters, 2010
- Mobile Phone Radiation Induces Reactive Oxygen Species Production and DNA Damage in Human Spermatozoa In VitroPLOS ONE, 2009
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?Nature Reviews Drug Discovery, 2009
- How mitochondria produce reactive oxygen speciesBiochemical Journal, 2008
- Nanoparticle Self-Lighting Photodynamic Therapy for Cancer TreatmentJournal of Biomedical Nanotechnology, 2008
- Phototoxicity of Zinc Oxide Nanoparticle Conjugatesin Human Ovarian Cancer NIH: OVCAR-3 CellsJournal of Biomedical Nanotechnology, 2008
- Elevated copper and oxidative stress in cancer cells as a target for cancer treatmentCancer Treatment Reviews, 2008