A Boron‐Based Synthesis of the Natural Product (+)‐trans‐Dihydrolycoricidine
- 31 March 2011
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 50 (18), 4189-4192
- https://doi.org/10.1002/anie.201007135
Abstract
Diastereoselective diboration results in the highly selective 1,4‐dihydroxylation of chiral cyclohexadienes (see scheme). Together with the catalytic enantioselective conjugate allylboration, the diene diboration facilitates the asymmetric synthesis of the cytotoxic agent (+)‐trans‐dihydrolycoricidine (1 ). pin=pinacol.Keywords
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