Physiologically activated phase transition systems for improved ocular retention of ketorolac tromethamine
Open Access
- 1 January 2012
- journal article
- Published by Medknow in Journal of Pharmacy And Bioallied Sciences
- Vol. 4 (5), 6-7
- https://doi.org/10.4103/0975-7406.94117
Abstract
In present investigation, novel physiologically activated phase transition systems for Ketorolac Tromethamine was developed. In-situ gelling systems: pH sensitive gel using carbopol 980 and HPMC K100LV, ion sensitive gel using gallan gum and temperature sensitive gel using Poloxamer 407 and Poloxamer 188 were developed. The drug content, content uniformity, pH, optical transmittance, rheological property, bioadhesive strength, in-vitro drug release, ocular irritation and stability study were evaluated. Characterization revealed that gels were conforming to all criteria required for ocular delivery in terms of stability on sterilization, long residence time, non-irritability and sustained drug release without affecting vision. Thus, In-situ gels can be a promising alternative to the prevalent market formulations.Keywords
This publication has 1 reference indexed in Scilit:
- The use of mucoadhesive polymers in ocular drug deliveryAdvanced Drug Delivery Reviews, 2005