Visceral hypersensitivity
Open Access
- 28 February 2003
- journal article
- review article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 17 (5), 623-633
- https://doi.org/10.1046/j.1365-2036.2003.01447.x
Abstract
Visceral hypersensitivity is highly prevalent in all functional bowel disorders. Most also demonstrate wider patterns of somatic referral of intestinal pain or discomfort. This hypersensitivity may explain the symptoms as the sensitive gut can be more easily provoked by normal or abnormal motor events in the gut. Visceral hypersensitivity may increase during psychosocial stress and during periods of symptom exacerbation, although this requires confirmation. Pharmacological therapy to reduce visceral hypersensitivity is now possible using antagonists to neurotransmitters, opening up an exciting new era for the treatment of functional gastrointestinal disorders.Keywords
This publication has 81 references indexed in Scilit:
- Psychological stress increases visceral sensitivity in patients with irritable bowel syndrome (IBS) but not controlsGastroenterology, 2001
- The 5-HT3 receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised ratGut, 2000
- Peripheral Opioid Modulation of Visceral PainaAnnals of the New York Academy of Sciences, 2000
- Neurokinin 3 receptors in the gut: A new target for the treatment of visceral pain?Gastroenterology, 1999
- Effects of the corticotropin‐releasing factor (CRF) on rectal afferent nerves in humansNeurogastroenterology & Motility, 1996
- Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the ratPain, 1995
- Contributions of anterior cingulate cortex to behaviourBrain, 1995
- Double-blind dose-response multicenter comparison of fedotozine and placebo in treatment of nonulcer dyspepsiaDigestive Diseases and Sciences, 1994
- Terminal ileal mucosal mast cells in irritable bowel syndromeDigestive Diseases and Sciences, 1993
- Activity-dependent neuronal plasticity following tissue injury and inflammationTrends in Neurosciences, 1992