Comparison of Sodium Valproate and Phenytoin as Single Drug Treatment in Epilepsy
- 1 February 1981
- Vol. 22 (1), 27-33
- https://doi.org/10.1111/j.1528-1157.1981.tb04330.x
Abstract
Epileptic patients (33) were randomly divided into 2 treatment groups. One group of 18 patients was given sodium valproate; the other 15 patients were given phenytoin. Periods of treatment ranged from 9-48 mo. (mean, 30 mo.). Any patient who developed a seizure while on the 1st drug was changed to the other drug, provided the serum level of the 1st drug was in the accepted therapeutic range. Six required the change from phenytoin to sodium valproate, and 3 from sodium valproate to phenytoin. Side effects were not a major problem with either drug during the trial period. Phenytoin has been widely prescribed alone. Sodium valproate may also be used as a single drug in the treatment of several types of epilepsy.Keywords
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