Endogenous opioid peptides and regulation of drinking and feeding
Open Access
- 1 November 1985
- journal article
- review article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 42 (5), 1099-1132
- https://doi.org/10.1093/ajcn/42.5.1099
Abstract
Considerable work across the last 10 yr has implicated the endogenous opioid peptides in the regulation of ingestion. The opioid antagonists, such as naloxone and naltrexone, reduce intake of water, flavored water, and food. Naloxone's effects are pharmacologically specific, ie, its effects are dose-related and stereoselective. Further, a variety of antagonists produce similar effects. A primary site of action of naloxone, with respect to intake, is in the central nervous system. Naloxone's effects are also behaviorally specific, ie, its effects seem particularly related to palatability functions. The effects of opioid agonists, in small doses, enhance intake of some nutrients, but these effects are not opposite those of the antagonists. Benzodiazepines enhance drinking and eating and apparently interact with opioid systems. These observations combine with those directly measuring features of the endogenous opioid peptides to support a conclusion that opioid peptides are part of a system for regulating ingestion.Keywords
This publication has 98 references indexed in Scilit:
- The effects of aging on opioid modulation of feeding in ratsLife Sciences, 1983
- Stress induced eatingLife Sciences, 1983
- Multiple benzodiazepine receptors: Structures in the brain or structures in the mind? A critical reviewLife Sciences, 1983
- Benzodiazepine-opiate antagonist interactions in relation to feeding and drinking behaviorLife Sciences, 1983
- Antagonistic effects of naloxone on CCK-octapeptide induced satiety and rumino-reticular hypomotility in sheepLife Sciences, 1983
- Ontogeny of opiate receptors in rat forebrain: Visualization by in vitro autoradiographyDevelopmental Brain Research, 1981
- Narcotic antagonists attenuate drinking induced by water deprivation in a primateLife Sciences, 1981
- Effect of naloxone on analgesia induced by food deprivationLife Sciences, 1979
- Suppression of appetitive behavior in the rat by naloxone: Lack of effect of prior morphine dependenceLife Sciences, 1979
- Stereospecific aversive property of narcotic antagonists in morphine-free ratsLife Sciences, 1978