The B-cell receptor of a hepatitis C virus (HCV)–associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis
Open Access
- 15 December 2001
- journal article
- Published by American Society of Hematology in Blood
- Vol. 98 (13), 3745-3749
- https://doi.org/10.1182/blood.v98.13.3745
Abstract
Hepatitis C virus (HCV) infection is associated with extrahepatic B-cell lymphoproliferative disorders. To determine whether a viral antigen drives this B-cell expansion, the B-cell receptors were cloned from HCV-associated lymphomas and were expressed as soluble immunoglobulins. The rescued immunoglobulins were then tested for their ability to bind the HCV-E2 envelope glycoprotein, an antigen that was previously implicated in the pathogenesis of HCV-associated B-cell diseases. One of 2 lymphoma immunoglobulin test cases bound the E2 protein in a manner identical to a bona fide human anti-E2 antibody. Moreover, it bound E2 from multiple viral genotypes, suggesting reactivity with a conserved E2 epitope. These findings support the hypothesis that some HCV-associated lymphomas originate from B cells that were initially activated by the HCV-E2 protein and might explain the association between HCV infection and some B-cell lymphoproliferative disorders.Keywords
This publication has 31 references indexed in Scilit:
- Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis CAnnals of Internal Medicine, 2000
- Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: Clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphomaArthritis & Rheumatism, 2000
- Hepatitis C: public health strategiesJournal of Hepatology, 1999
- The etiology and pathophysiology of mixed cryoglobulinemia secondary to hepatitis C virus infectionSpringer Seminars in Immunopathology, 1997
- Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number.JCI Insight, 1996
- Mixed cryoglobulinemia as a possible preneoplastic disorderArthritis & Rheumatism, 1995
- Hepatitis C virus infection in patients with non‐Hodgkin's lymphomaBritish Journal of Haematology, 1994
- A Role for Hepatitis C Virus Infection in Type II CryoglobulinemiaNew England Journal of Medicine, 1992
- A common idiotope on human rheumatoid factors identified by a hybridoma antibodyMolecular Immunology, 1983
- Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype.Proceedings of the National Academy of Sciences of the United States of America, 1981