Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin–neurophysin II precursor
- 1 January 1982
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 295 (5847), 299-303
- https://doi.org/10.1038/295299a0
Abstract
The sequence of a cDNA encoding the nonapeptide arginine vasopressin (AVP) and its carrier protein, neurophysin II (NpII) from bovine hypothalamus, proves that the 166-amino acid precursor molecule contains a signal peptide of 19 amino acids followed directly by AVP connected to NpII by a Gly-Lys-Arg sequence. The carboxy-terminal region of the precursor contains a naturally occurring glycopolypeptide of 39 amino acids which is separated from NpII by a single arginine residue.Keywords
This publication has 67 references indexed in Scilit:
- Synthesis, Transport, and Release of Posterior Pituitary HormonesScience, 1980
- Chemistry and Biology of the NeurophysinsAnnual Review of Biochemistry, 1979
- The Hypothalamic-Neurohypophysial System of the Rat: Localization and Quantitation of Neurophysin by Light Microscopic Immunocytochemistry in Normal Rats and in Brattleboro Rats Deficient in Vasopressin and a NeurophysinEndocrinology, 1976
- THE ROLE OF NEUROPHYSIN PROTEINS: SUGGESTIONS FROM THE STUDY OF THEIR TRANSPORT AND TURNOVER*Annals of the New York Academy of Sciences, 1975
- INTRODUCTORY REMARKSAnnals of the New York Academy of Sciences, 1975
- QUANTIFICATION OF RAT NEUROPHYSINS BY POLYACRYLAMIDE GEL ELECTROPHORESIS (PAGE): APPLICATION TO THE RAT WITH HEREDITARY HYPOTHALAMIC DIABETES INSIPIDUS*Annals of the New York Academy of Sciences, 1975
- Tentative identification of a vasopressin–neurophysin and an oxytocin–neurophysin in the ratBiochemical Journal, 1971
- Changes in Neurohypophysial Proteins Induced by Dehydration and Ingestion of Saline1Endocrinology, 1967
- Neurohypophysial Principles in Rats Homozygous and Heterozygous for Hypothalamic Diabetes Insipidus (Brattleboro Strain)Endocrinology, 1965
- Evidence for a Precursor in Vasopressin BiosynthesisEndocrinology, 1964