Inhibition of Type III Secretion inSalmonella entericaSerovar Typhimurium by Small-Molecule Inhibitors
- 1 July 2007
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 51 (7), 2631-2635
- https://doi.org/10.1128/aac.01492-06
Abstract
Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.Keywords
This publication has 33 references indexed in Scilit:
- A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatisProceedings of the National Academy of Sciences of the United States of America, 2006
- Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycleMolecular Microbiology, 2006
- The functional interface between Salmonella and its host cell: opportunities for therapeutic interventionTrends in Pharmacological Sciences, 2005
- Transcriptional Inhibitor of Virulence Factors in EnteropathogenicEscherichia coliAntimicrobial Agents and Chemotherapy, 2005
- Small-Molecule Inhibitors Specifically Targeting Type III SecretionInfection and Immunity, 2005
- Identification of host‐specific colonization factors of Salmonella enterica serovar TyphimuriumMolecular Microbiology, 2004
- The YopD Translocator of Yersinia pseudotuberculosis Is a Multifunctional Protein Comprised of Discrete DomainsJournal of Bacteriology, 2004
- Targeting Bacterial Virulence: Inhibitors of Type III Secretion in YersiniaCell Chemical Biology, 2003
- SalmonellaInteractions with Host Cells: Type III Secretion at WorkAnnual Review of Cell and Developmental Biology, 2001
- Molecular basis of Salmonella‐induced enteritisMolecular Microbiology, 2000