The Purine Path to Chemotherapy
- 7 April 1989
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 244 (4900), 41-47
- https://doi.org/10.1126/science.2649979
Abstract
Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).Keywords
This publication has 95 references indexed in Scilit:
- Vidarabine versus Acyclovir Therapy in Herpes Simplex EncephalitisThe New England Journal of Medicine, 1986
- Conversion of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine to acyclovir as catalyzed by adenosine deaminaseBiochemical Pharmacology, 1983
- Treatment of First Episodes of Genital Herpes Simplex Virus Infection with Oral AcyclovirThe New England Journal of Medicine, 1983
- Activation by thymidine kinase and potent antiherpetic activity of 2′-nor-2′-deoxyguanosine (2′NDG)Biochemical and Biophysical Research Communications, 1982
- Acyclovir Prophylaxis of Herpes-Simplex-Virus InfectionsThe New England Journal of Medicine, 1981
- ENHANCEMENT OF ANTIBODY SYNTHESIS BY 6-MERCAPTOPURINEThe Journal of Experimental Medicine, 1966
- Condensed Pyrimidine Systems. XX. Purines Related to 6-Mercaptopurine and ThioguanineJournal of the American Chemical Society, 1959
- Studies on Condensed Pyrimidine Systems. IX. The Synthesis of Some 6-Substituted PurinesJournal of the American Chemical Society, 1952
- STUDIES ON ANALOGS OF PURINES AND PYRIMIDINESAnnals of the New York Academy of Sciences, 1950
- The Effects of Pyrimidines on the Growth of Lactobacillus caseiScience, 1945