HISTORY OF THE CUSHING REFLEX
- 1 November 2006
- journal article
- other
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurosurgery
- Vol. 59 (5), 1132-1137
- https://doi.org/10.1227/01.neu.0000245582.08532.7c
Abstract
INCREASING SYSTOLIC AND pulse pressure with bradycardia and respiratory irregularity are signs of increased intracranial pressure, leading to cerebral herniation and fatal brainstem compression. This phenomenon, the vasopressor response, is generally known as the Cushing reflex based on Harvey Cushing's experimental work in Europe in 1901 and 1902. However, similar experiments had been carried out decades earlier by others, notably Paul Cramer, Ernst von Bergmann, Ernst von Leyden, Georg Althann, Friedrich Jolly, Friedrich Pagenstecher, Henri Duret, Bernard Naunyn, and Julius Schreiber. Cushing initially failed to give credit to the work of these predecessors. Nonetheless, he studied the brain's reaction to compression more carefully than previous researchers and offered an improved explanation of the pathophysiology of the phenomenon named after him.Keywords
This publication has 9 references indexed in Scilit:
- From Trephination to Tailored Resection: Neurosurgery in Germany before World War IINeurosurgery, 2005
- Harvey Cushing's Paradigmatic Contribution to Neurosurgery and the Evolution of His Thoughts about SpecializationThe SHAFR Guide Online, 2003
- The Neuron Doctrine, the Mind, and the ArcticNeurosurgery, 2000
- The Neuron Doctrine, the Mind, and the ArcticNeurosurgery, 2000
- Early Neuroscience Research at the Medical Faculty of Tartu University in EstoniaNeurosurgery Quarterly, 1998
- The crucial decade: modern neurosurgery's definitive development in Harvey Cushing's early research and practice, 1900 to 1910Journal of Neurosurgery, 1997
- German Influences on the Work of Harvey Cushing, the Pioneer of Neurosurgery in AmericaNeurosurgery, 1981
- THE BLOOD-PRESSURE REACTION OF ACUTE CEREBRAL COMPRESSION, ILLUSTRATED BY CASES OF INTRACRANIAL HEMORRHAGE.The American Journal of the Medical Sciences, 1903
- SOME EXPERIMENTAL AND OLINICAL OBSERVATIONS CONOERNING STATES OF INCREASED INTRACRANIAL TENSIONThe American Journal of the Medical Sciences, 1902