Eye-Preserving Therapy in Retinoblastoma: Prolonged Primary Chemotherapy Alone or Combined with Local Therapy
Open Access
- 1 January 2010
- journal article
- research article
- Published by Korean Ophthalmological Society in Korean Journal of Ophthalmology
- Vol. 24 (4), 219-224
- https://doi.org/10.3341/kjo.2010.24.4.219
Abstract
To evaluate the efficacy of primary chemotherapy combined with local therapy in the treatment of retinoblastomas not treatable with a single therapeutic method. We performed a retrospective chart review of 227 patients diagnosed with retinoblastoma. Sixty-five eyes in 52 patients had tumors not treatable with a single therapeutic method and received primary chemotherapy combined with local therapy as needed. Tumor control and eye salvage was achieved in 34 of the 65 eyes; the probability of ocular survival was 46.56% using the Kaplan-Meier method. Forty-three of the 65 eyes were group D or E tumors, in which tumor control and eye salvage was achieved in 16 eyes. Twenty eyes were treated with chemotherapy only, while 28 eyes received one additional modality of local therapy, and 17 eyes received two modalities of local therapy. Of the eyes treated with chemotherapy only, tumor control was achieved in 5 eyes. Primary chemotherapy combined with local therapy can be effective and safe in the treatment of retinoblastomas otherwise untreatable with other therapeutic methods, such as group D and E retinoblastomas. More vigorous treatment with more local therapeutic methods combined may yield even better results.Keywords
This publication has 23 references indexed in Scilit:
- Chemoreduction for Group E Retinoblastoma: Comparison of Chemoreduction Alone Versus Chemoreduction Plus Low-Dose External Radiotherapy in 76 EyesOphthalmology, 2009
- The success of primary chemotherapy for group D heritable retinoblastomaBritish Journal of Ophthalmology, 2008
- Intraocular Retinoblastoma: the Case for a New Group ClassificationOphthalmology Clinics of North America, 2005
- Causes of chemoreduction failure in retinoblastoma and analysis of associated factors leading to eventual treatment with external beam radiotherapy and enucleationOphthalmology, 2004
- Chemoreduction for retinoblastoma. Analysis of tumor control and risks for recurrence in 457 tumorsAmerican Journal of Ophthalmology, 2004
- Chemoreduction plus focal therapy for retinoblastoma: factors predictive of need for treatment with external beam radiotherapy or enucleationAmerican Journal of Ophthalmology, 2002
- Combined chemotherapy and local treatment in the management of intraocular retinoblastomaMedical and Pediatric Oncology, 2002
- Chemotherapy for Eye CancerSurvey of Ophthalmology, 2001
- Chemotherapy With Focal Therapy Can Cure Intraocular Retinoblastoma Without RadiotherapyAmerican Journal of Ophthalmology, 1996
- Mortality From Second Tumors Among Long-Term Survivors of RetinoblastomaJNCI Journal of the National Cancer Institute, 1993