Regulatory circuits of T cell function in cancer
Top Cited Papers
- 16 August 2016
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 16 (10), 599-611
- https://doi.org/10.1038/nri.2016.80
Abstract
Recent progress in cancer immunotherapy emphasizes the importance of understanding immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to mechanisms that are evolutionarily conserved or acquired by somatic mutations. The dysfunctional state of T cells has been termed 'exhaustion', on the basis of similarities to dysfunctional T cells in chronic infections. However, despite shared properties, recent studies have identified marked differences between T cell dysfunction in cancer and chronic infection. In this Review, we discuss T cell-intrinsic molecular alterations and metabolic communication in the tumour microenvironment. Identification of the underlying molecular drivers of T cell dysfunction is essential for the continued progress of cancer research and therapy.Keywords
This publication has 162 references indexed in Scilit:
- Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiationNature Immunology, 2013
- Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T CellsCancer Cell, 2012
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory DevelopmentImmunity, 2011
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte ActivationImmunity, 2011
- A human memory T cell subset with stem cell–like propertiesNature Medicine, 2011
- Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATFNature Medicine, 2010
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent MannerCancer Cell, 2010
- A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral InfectionImmunity, 2009
- Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral InfectionImmunity, 2007
- The Hallmarks of CancerCell, 2000