Comparison of strains of mycobacterium tuberculosis from british, ugandan and asian immigrant patients: A study in bacteriophage typing, susceptibility to hydrogen peroxide and sensitivity to thiophen-2-carbonic acid hydrazide
- 1 December 1977
- journal article
- research article
- Published by Elsevier BV in Tubercle
- Vol. 58 (4), 207-215
- https://doi.org/10.1016/0041-3879(77)90045-9
Abstract
Strains of Mycobacterium tuberculosis were obtained from 65 patients with pulmonary tuberculosis resident in Uganda, and from pulmonary and extrapulmonary tuberculosis in 42 British patients of European ethnic stock and in 67 Asian immigrants, often from Uganda, resident in Britain. The bacteriophage-type patterns of the African, British and Asian strains were different. The pattern for the Asian strains resembled that found previously in patients from South India, suggesting that there has been little interchange of organisms between the Asian community and the African and British communities alongside whom they have lived. The patterns for pulmonary and extra-pulmonary tuberculosis were similar. Strains of bacteriophage type 1, mainly obtained from Asians, were characterized by a greater susceptibility to the bactericidal activity of hydrogen-peroxide and/or a greater sensitivity to thiophen-2-carbonic acid hydrazide than strains of other types. Des souches de Mycobacterium tuberculosis ont été isolées à partir de 65 malades atteints de tuberculose pulmonaire résidant en Ouganda et de 42 cas de tuberculose pulmonaire et extra-pulmonaire chez des anglais d'origine ethnique européenne et 67 immigrants asiatiques, souvent originaires d'Ouganda, résidant en Grande- Bretagne. Les profilsdetypisation parlebactériophageétaientdifférentspour les souches africaine, anglaise et asiatique. Le profil pour les souches asiatiques ressemblait à celui trouvé antérieurement chez des malades du Sud de I'Inde, ce qui laisse à penser qu'il y avait eu peu d'échanges entre les communautés asiatique, d'une part, et les communautés africaine et britannique, d'autre part, aux côtés desquelles les premieres avaient vécu. Les prof ils obtenus pour les bacilles isolés des cas de tuberculose pulmonaire et extra-pulmonaire étaient similaires. Les souches correspondant au bactériophage type 1 obtenues essentiellement a partir de malades asiatiques étaient caractérisées par leur plus grande sensibilite à l'action bactericide du peroxide d'hydrogène et/ou par une plus grande sensibilite à I'hydrazide de l'acide thiophène-2-carbonique que les souches des autres types. Se obtuvieron cepas de Micobacterium tuberculosis de 65 pacientes con tuberculosis pulmonar residentes en Uganda, de 42 pacientes británicos de origen étnico europeo portadores de tuberculosis pulmonary extrapulmonar y de 67 inmigrantes asiáticos, frecuentemente provenientes de Uganda, residentes en Inglaterra. Los tipos bacteriófagos de las cepas africanas, inglesas y asiáticas se parecieron a aquellos encontrados en enfermos del sur de la India, to que sugiere poco intercambio de organismos entre la comunidad asiática y las comunidades africana y británica, a cuyo lado han vivido. Los tipos de tuberculosis pulmonar y extrapulmonar fueron similares. Las cepas de bacteriófago tipo I, obtenidas principalmente de asiáticos, se caracterizaron por una susceptibilidad mayor a la actividad bactericida del peróxido de hidrógeno y/o una major sensibilidad a la hidracida del ácido tiopen-2carbónico, que las cepas de otros tipos.This publication has 15 references indexed in Scilit:
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