Epigenetic Control of Hematopoietic Stem Cell Aging The Case of Ezh2
- 18 April 2007
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1106 (1), 233-239
- https://doi.org/10.1196/annals.1392.008
Abstract
Hematopoietic stem cells have potent, but not unlimited, selfrenewal potential. The mechanisms that restrict selfrenewal are likely to play a role during aging. Recent data suggest that the regulation of histone modifications by Polycomb group genes may be of crucial relevance to balance selfrenewal and aging. We provide evidence for the involvement of one of these Polycomb group genes, Ezh2, in aging of the hematopoietic stem cell system.Keywords
This publication has 40 references indexed in Scilit:
- Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisNature, 2005
- Oncogene-induced senescence as an initial barrier in lymphoma developmentNature, 2005
- Senescence in premalignant tumoursNature, 2005
- Quantification of Self-Renewal Capacity in Single Hematopoietic Stem Cells from Normal and Lnk-Deficient MiceDevelopmental Cell, 2005
- Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad NeighborsCell, 2005
- Reversal of human cellular senescence: roles of the p53 and p16 pathwaysThe EMBO Journal, 2003
- Cellular senescence as a tumor-protection mechanism: the essential role of countingCurrent Opinion in Genetics & Development, 2001
- The biology of replicative senescenceEuropean Journal Of Cancer, 1997
- Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem CellScience, 1996
- The serial cultivation of human diploid cell strainsExperimental Cell Research, 1961