Immune system adaptation in elite athletes
- 1 November 2006
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Clinical Nutrition and Metabolic Care
- Vol. 9 (6), 659-665
- https://doi.org/10.1097/01.mco.0000247476.02650.18
Abstract
To evaluate the effects of exercise on immune function in relation to infection susceptibility. Postexercise immune function depression is most pronounced when exercise is continuous, prolonged, of moderate to high intensity and performed without food intake. Periods of intensified training that result in overreaching have been shown to chronically depress immune function, with leukocyte functions measured at rest still depressed 24 h after the last exercise bout. Several studies indicate that the incidence of symptoms of upper respiratory tract illness is increased in the days following prolonged strenuous endurance events and it has been generally assumed that this is due to the temporary exercise-induced depression of immune function. More recently it has been proposed that at least some of these symptoms are attributable to inflammation of the upper respiratory tract rather than to infectious episodes. Although elite athletes are not clinically immune deficient, it is possible that the combined effects of small changes in several immune parameters may compromise resistance to common minor illnesses. Although it is possible that immune depression linked with prolonged intensive training may determine susceptibility to infection, convincing evidence of a cause and effect relationship remains elusive.Keywords
This publication has 18 references indexed in Scilit:
- Influence of exercise training and age on CD14+ cell-surface expression of toll-like receptor 2 and 4Brain, Behavior, and Immunity, 2005
- The physiological regulation of toll‐like receptor expression and function in humansJournal Of Physiology-London, 2005
- Inflammation: the link between insulin resistance, obesity and diabetesTrends in Immunology, 2004
- IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humansAmerican Journal of Physiology-Endocrinology and Metabolism, 2003
- Moderate to vigorous physical activity and risk of upper-respiratory tract infectionMedicine & Science in Sports & Exercise, 2002
- Production of interleukin‐6 in contracting human skeletal muscles can account for the exercise‐induced increase in plasma interleukin‐6Journal Of Physiology-London, 2000
- Similarities and differences of the immune response to exercise and trauma: the IFN-γ conceptCanadian Journal of Physiology and Pharmacology, 1998
- Adrenal Hormone Modulation of Type 1 and Type 2 Cytokine Production by Spleen Cells: Dexamethasone and Dehydroepiandrosterone Suppress Interleukin-2, Interleukin-4, and Interferon-γ Productionin VitroCellular Immunology, 1998
- Exercise, Infection, and ImmunityInternational Journal of Sports Medicine, 1994
- Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runnersThe American Journal of Clinical Nutrition, 1993