Tularemia Outbreaks in Spain from 2007 to 2020 in Humans and Domestic and Wild Animals
Open Access
- 14 July 2021
- Vol. 10 (7), 892
- https://doi.org/10.3390/pathogens10070892
Abstract
In this study, tularemia outbreaks associated with humans and several domestic and wild animals (Iberian hares, wild rabbits, voles, mice, grey shrews, sheep, dogs, foxes, wolves, ticks, and river crayfish) are reported in Spain from 2007 to 2020. Special attention was paid to the outbreaks in humans in 2007–2009 and 2014–2015, when the most important waves occurred. Moreover, positive rates of tularemia in lagomorphs were detected in 2007–2010, followed by negative results in 2011–2013, before again returning to positive rates in 2014 and in 2017 and in 2019–2020. Lagomorphs role in spreading Francisella tularensis in the epidemiological chain could not be discarded. F. tularensis is described for the first time infecting the shrew Crocidura russula worldwide, and it is also reported for the first time infecting wild rabbits (Oryctolagus cuniculus) in Spain. Serological positives higher than 0.4% were seen for sheep only from 2007–2009 and again in 2019, while serological rates greater than 1% were revealed in dogs in 2007–2008 and in wild canids in 2016. F. tularensis were detected in ticks in 2009, 2014–2015, 2017, and 2019. Lastly, negative results were achieved for river crayfish and also in environmental water samples from 2007 to 2020.Keywords
Funding Information
- Dirección General de Producción Agropecuaria e Infraestructuras, Servicio de Sanidad Animal, Consejería de Agricultura y Ganadería, Junta de Castilla y León (not described)
This publication has 29 references indexed in Scilit:
- Francisella tularensisSubspeciesholarctica, Tasmania, Australia, 2011Emerging Infectious Diseases, 2012
- Humans and evolutionary and ecological forces shaped the phylogeography of recently emerged diseasesNature Reviews Microbiology, 2009
- Phylogeography of Francisella tularensis : Global Expansion of a Highly Fit CloneJournal of Bacteriology, 2009
- Rapid diagnosis and quantification of Francisella tularensis in organs of naturally infected common squirrel monkeys (Saimiri sciureus)Veterinary Microbiology, 2008
- Genomic Deletion Marking an Emerging Subclone of Francisella tularensis subsp. holarctica in France and the Iberian PeninsulaApplied and Environmental Microbiology, 2007
- Canonical Insertion-Deletion Markers for Rapid DNA Typing ofFrancisella tularensisEmerging Infectious Diseases, 2007
- In vitro susceptibility of field isolates of Francisella tularensis subsp. holarctica recovered in Spain to several antimicrobial agentsResearch in Veterinary Science, 2004
- Genotyping of Francisella tularensis Strains by Pulsed-Field Gel Electrophoresis, Amplified Fragment Length Polymorphism Fingerprinting, and 16S rRNA Gene SequencingJournal of Clinical Microbiology, 2002
- Waterborne Outbreak of Tularemia Associated with Crayfish FishingEmerging Infectious Diseases, 2001
- Tularemia: Association with hunting and farmingFEMS Immunology & Medical Microbiology, 1996