Heterocyclization of Functionalized Vinylic Derivatives of Imidazo[1,2-a]pyridines
- 8 September 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 66 (20), 6576-6584
- https://doi.org/10.1021/jo015582x
Abstract
Heterocyclization of functionalized vinylic derivatives of imidazo[1,2-a]pyridines was explored experimentally and theoretically using semiempirical AM1 and ab initio methods. A range of functionalized vinylic derivatives (azido, amino, and carbodiimide groups) were prepared for conversion into pyrroloazaindoles 19-22, imidazo[1,x]-, (x = 5, 6, 7, 8), [2,6]-, and [2,7]naphthyridines 28-30, 35-38 by thermal reaction. In the case of vinylic groups in the 5 position, peri annulation also was observed. The experimental and theoretical data are compared and discussed.Keywords
This publication has 94 references indexed in Scilit:
- Research on heterocyclic compounds. XXXII. Synthesis and cyclooxygenase-independent antiinflammatory and analgesic activity of imidazo[1,2-a]pyrimidine derivativesEuropean Journal of Medicinal Chemistry, 1994
- Imidazo(1,2-a)pyridines. I. Synthesis and Inotropic Activity of New 5-Imidazo(1,2-a)pyridinyl-2(1H)-pyridinone Derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1991
- Synthesis and Absolute Configuration of Wybutine, the Fluorescent Minor Base from Phenylalanine Transfer Ribonucleic Acids.CHEMICAL & PHARMACEUTICAL BULLETIN, 1991
- Synthesis of Kifunensine, an Immunomodulating Substance Isolated from a Microbial Source.CHEMICAL & PHARMACEUTICAL BULLETIN, 1991
- Structure of Kifunensine, a New Immunomodulator Isolated from an Actinomycete.CHEMICAL & PHARMACEUTICAL BULLETIN, 1991
- Synthesis of 1H-imidazo(1,2-a)pyrazolo(3,4-c)pyridines.CHEMICAL & PHARMACEUTICAL BULLETIN, 1990
- Studies on the imidazo[1,2-a]pyridinic system: Synthesis of pyrido[1',2':1,2]imidazo[5,4-d][1.3]-benzodiazepines.CHEMICAL & PHARMACEUTICAL BULLETIN, 1989
- Coupling of cyclopropapyrroloindole (CPI) derivatives. The preparation of CC-1065, ent-CC-1065, and analogsJournal of the American Chemical Society, 1987
- Reaction of 3-substituted imidazo[1,2-a]pyridines with bromine(1+) and the alleged 5-bromo-substituted productThe Journal of Organic Chemistry, 1980
- Synthesis of mutagenic principles isolated from L-glutamic acid pyrolysate.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978