Perioperative administration of antimicrobials associated with elective surgery for cranial cruciate ligament rupture in dogs: 83 cases (2003–2005)
- 1 July 2006
- journal article
- Published by American Veterinary Medical Association (AVMA) in Journal of the American Veterinary Medical Association
- Vol. 229 (1), 92-95
- https://doi.org/10.2460/javma.229.1.92
Abstract
Objective—To evaluate perioperative antimicrobial use associated with elective surgery for cranial cruciate ligament rupture in dogs. Design—Retrospective case series. Animals—83 dogs. Procedures—Medical records were reviewed and antimicrobial use practices were evaluated for dogs with no other problems that would affect antimicrobial use decisions. Results—Antimicrobials were administered before or during surgery to 75 of 83 (90%) dogs. Timing of administration with respect to first incision, intraoperative administration, and duration of administration were variable. Antimicrobial administration began after surgery in 3 (3.6%) dogs. Fifty-five of 65 (85%) dogs treated before surgery received the first dose within 60 minutes of the first incision. Time from first antimicrobial administration to closure of the incision ranged from 15 to 285 minutes (mean ± SD, 141 ± 53 minutes). If a guideline of repeated administration every 2 hours after first administration until closure of the surgical site was used, 22 of 43 (51%) dogs received the required intraoperative dose, whereas 6 of 32 (19%) dogs that did not require intraoperative treatment were treated. Twenty-four (29%) dogs received antimicrobials after surgery. Conclusions and Clinical Relevance—Certain discrepancies between antimicrobial use practices in this study and standard guidelines used in human medicine were evident.Keywords
This publication has 9 references indexed in Scilit:
- Impact of local guidelines and an integrated dispensing system on antibiotic prophylaxis quality in a surgical centreJournal of Hospital Infection, 2005
- Antimicrobial prophylaxis for surgery: An advisory statement from the National Surgical Infection Prevention ProjectThe American Journal of Surgery, 2005
- Adherence to local hospital guidelines for surgical antimicrobial prophylaxis: a multicentre audit in Dutch hospitalsJournal of Antimicrobial Chemotherapy, 2003
- The effects of sodium ampicillin, sodium cefazolin, and sodium cefoxitin on blood pressures and heart rates in healthy, anesthetized dogsJournal of the American Animal Hospital Association, 2000
- ASHP Therapeutic Guidelines on Antimicrobial Prophylaxis in SurgeryAmerican Journal of Health-System Pharmacy, 1999
- Cephalothin and Cefazolin In Vitro Antibacterial Activity and Pharmacokinetics in DogsVeterinary Surgery, 1995
- Survey of guidelines for antimicrobial prophylaxis in surgeryJournal of Hospital Infection, 1993
- Surgical Wound Infection Rates in Dogs and Cats Data from a Teaching HospitalVeterinary Surgery, 1988
- Antibiotic Prophylaxis in Gastric, Biliary and Colonic SurgeryAnnals of Surgery, 1976