Gallium-containing anticancer compounds
- 1 June 2012
- journal article
- review article
- Published by Future Science Ltd in Future Medicinal Chemistry
- Vol. 4 (10), 1257-1272
- https://doi.org/10.4155/fmc.12.69
Abstract
There is an ever pressing need to develop new drugs for the treatment of cancer. Gallium nitrate, a group IIIa metal salt, inhibits the proliferation of tumor cells in vitro and in vivo and has shown activity against non-Hodgkin’s lymphoma and bladder cancer in clinical trials. Gallium can function as an iron mimetic and perturb iron-dependent proliferation and other iron-related processes in tumor cells. Gallium nitrate lacks crossresistance with conventional chemotherapeutic drugs and is not myelosuppressive; it can be used when other drugs have failed or when the blood count is low. Given the therapeutic potential of gallium, newer generations of gallium compounds are now in various phases of preclinical and clinical development. These compounds hold the promise of greater anti-tumor activity against a broader spectrum of cancers. The development of gallium compounds for cancer treatment and their mechanisms of action will be discussed.Keywords
This publication has 88 references indexed in Scilit:
- Ferroportin and Iron Regulation in Breast Cancer Progression and PrognosisScience Translational Medicine, 2010
- A novel gallium compound synergistically enhances bortezomib-induced apoptosis in mantle cell lymphoma cellsLeukemia Research, 2010
- Medical Applications and Toxicities of Gallium CompoundsInternational Journal of Environmental Research and Public Health, 2010
- Phase I Trial of Pelvic Radiation, Weekly Cisplatin, and 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone (3-AP, NSC #663249) for Locally Advanced Cervical CancerClinical Cancer Research, 2010
- Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole ComplexesBioinorganic Chemistry and Applications, 2010
- Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cellsFree Radical Biology & Medicine, 2008
- Development of Gallium Compounds for Treatment of Lymphoma: Gallium Maltolate, a Novel Hydroxypyrone Gallium Compound, Induces Apoptosis and Circumvents Lymphoma Cell Resistance to Gallium NitrateThe Journal of pharmacology and experimental therapeutics, 2007
- Gallium nitrate for the treatment of non-Hodgkin’s lymphomaExpert Opinion on Investigational Drugs, 2004
- Chemistry and Pharmacokinetics of Gallium Maltolate, a Compound With High Oral Gallium BioavailabilityMetal-Based Drugs, 2000
- Gallium NitrateDrugs, 1991