Prevalence of Subcortical Vascular Lesions and Association With Executive Function in Mild Cognitive Impairment Subtypes
- 1 September 2007
- journal article
- letter
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 38 (9), 2595-2597
- https://doi.org/10.1161/strokeaha.107.486407
Abstract
Background and Purpose— Subcortical hyperintensities (SH) have not been systematically evaluated in mild cognitive impairment (MCI). We sought to describe their frequency and distribution, and to test their association with cognitive characteristics in MCI patients. Methods— We performed standardized neuropsychological tests and an MRI scan in 170 consecutive MCI patients. Medial temporal lobe atrophy and SH, including periventricular, lobar white matter, basal ganglia and infratentorial hyperintensities, were assessed with visual semiquantitative scales. Results— The median age was 68.1 years (range: 45.5 to 87.0), and the median Mini-Mental State Examination score 28.0 (range: 26.0 to 30.0). MCI subtypes were amnestic single domain (21.2%), amnestic multiple domain (52.3%), nonamnestic single domain (21.8%), and nonamnestic multiple domain (4.7%). SH were found in 157 patients (92.6%); periventricular hyperintensities (80.6%) and lobar white matter hyperintensities (83.5%) were the most prominent locations. There was no association between SH and MCI subtypes. Executive dysfunction was independently associated with SH (odds ratio=2.53, 95% CI: 1.20 to 5.32), periventricular hyperintensities (odds ratio=2.51, 95% CI: 1.13 to 5.55), and white matter hyperintensities (odds ratio=2.08, 95% CI: 1.01 to 4.25). Conclusions— The prevalence of SH is high in MCI patients, irrespective of MCI subtypes. SH (especially periventricular hyperintensities, and lobar white matter hyperintensities) are associated with executive dysfunction.This publication has 12 references indexed in Scilit:
- Subcortical Hyperintensities Are Associated With Cognitive Decline in Patients With Mild Cognitive ImpairmentStroke, 2007
- Association of White Matter Hyperintensity Volume With Decreased Cognitive FunctioningArchives of Neurology, 2006
- Natural history of primary progressive aphasiaNeurology, 2005
- Mild cognitive impairment as a diagnostic entityJournal of Internal Medicine, 2004
- White matter lesions impair frontal lobe function regardless of their locationNeurology, 2004
- MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer’s diseaseNeurology, 2001
- Pathologic correlates of incidental MRI white matter signal hyperintensitiesNeurology, 1993
- A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imagingJournal of the Neurological Sciences, 1993
- Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates.Journal of Neurology, Neurosurgery & Psychiatry, 1992
- Senile Dementia of the Binswanger TypeJAMA, 1987