Osteosarcoma in children 5 years of age or younger at initial diagnosis
- 25 June 2010
- journal article
- research article
- Published by Wiley in Pediatric Blood & Cancer
- Vol. 55 (2), 285-289
- https://doi.org/10.1002/pbc.22509
Abstract
Background Since osteosarcoma is extremely rare in children ≤5 years of age, we sought to investigate if tumor characteristics, treatment strategies, and outcomes differ compared to older patients. Procedure Patients P = 0.006). These very young patients had a significantly higher proportion of telangiectatic histology (10.2% vs. 2.9%; P = 0.017). Sex, metastatic status, race, or ethnicity did not differ by age. A higher proportion of very young patients was treated with amputation (55.2% vs. 27.3%; P = 0.002). Five‐year overall survival was inferior for patients with localized osteosarcoma 5 years of age or younger compared to older children (51.9% vs. 67.3%; P = 0.03). After controlling for metastatic status, year of diagnosis, and tumor site, the hazard ratio for death in very young patients was 1.6 (95% confidence interval 1.02–2.36; P = 0.04) compared to older patients. Conclusions Tumor characteristics, treatment, and outcomes differ among children ≤5 years of age compared to older pediatric patients. These differences may reflect differences in tumor biology. Pediatr Blood Cancer. 2010;55:285–289. © 2010 Wiley–Liss, Inc.Keywords
This publication has 38 references indexed in Scilit:
- International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly personsInternational Journal of Cancer, 2009
- Clinicopathologic Features of Osteosarcoma in Patients With Rothmund-Thomson SyndromeJournal of Clinical Oncology, 2007
- The Survival of Osteosarcoma Patients 10 Years Old or Younger Is Not Worse than the Survival of Older Patients: A Retrospective AnalysisCancer Research and Treatment, 2007
- Osteosarcoma in Pre-adolescent PatientsJournal of International Medical Research, 2006
- Local control in childhood extremity sarcomas: Salvaging limbs and sparing functionMedical and Pediatric Oncology, 2003
- Early Multicenter Experience With a Noninvasive Expandable ProsthesisPublished by Ovid Technologies (Wolters Kluwer Health) ,2003
- Osteosarcoma in children under three years of ageMedical and Pediatric Oncology, 2003
- Etiology of OsteosarcomaPublished by Ovid Technologies (Wolters Kluwer Health) ,2002
- Survival, prognosis, and therapeutic response in osteogenic sarcoma. The memorial hospital experienceCancer, 1992
- Clinical Pharmacokinetics of Methotrexate in ChildrenClinical Pharmacokinetics, 1984