Cardiovascular Disease Risk in the Offspring of Diabetic Women: The Impact of the Intrauterine Environment
Open Access
- 22 October 2012
- journal article
- review article
- Published by Hindawi Limited in Experimental Diabetes Research
- Vol. 2012, 1-10
- https://doi.org/10.1155/2012/565160
Abstract
The incidence of gestational diabetes is increasing worldwide, exposing large numbers of infants to hyperglycaemia whilstin utero. This exposure may have a long-term negative impact on the cardiovascular health of the offspring. Novel methods to assess cardiovascular status in the neonatal period are now available—including measuring arterial intima-media thickness and retinal photography. These measures will allow researchers to assess the relative impact of intrauterine exposures, distinguishing these from genetic or postnatal environmental factors. Understanding the long-term impact of the intrauterine environment should allow the development of more effective health policy and interventions to decrease the future burden of cardiovascular disease. Initiating disease prevention aimed at the developing fetus during the antenatal period may optimise community health outcomes.Keywords
This publication has 81 references indexed in Scilit:
- Associations of Gestational Diabetes, Existing Diabetes, and Glycosuria With Offspring Obesity and Cardiometabolic OutcomesDiabetes Care, 2011
- Diagnosis and Classification of Diabetes MellitusDiabetes Care, 2010
- Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective studyCardiovascular Ultrasound, 2009
- Maternal diabetes alters transcriptional programs in the developing embryoBMC Genomics, 2009
- Risk Factors Associated With Aortic and Carotid Intima-Media Thickness in Adolescents and Young Adults: The Muscatine Offspring StudyJournal of the American College of Cardiology, 2009
- ADOLESCENTS WITH TYPE 2 DIABETESRetina, 2009
- Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crestMechanisms of Development, 2008
- Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemiaThe Journal of Experimental Medicine, 2008
- Propagation of the cardiac impulse in the diabetic rat heart: reduced conduction reserveJournal Of Physiology-London, 2007
- Mannheim Carotid Intima-Media Thickness Consensus (2004–2006)Cerebrovascular Diseases, 2006