Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation.
Open Access
- 1 February 1976
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 57 (2), 526-529
- https://doi.org/10.1172/jci108306
Abstract
Nonsuppressible insulin-like activity soluble in acid ethanol (NSILA-s) is a well-characterized peptide derived from human serum which has previously been shown to have insulin-like bioactivity and react with both insulin and NSILA-s receptor sites in liver plasma membranes. In the present study we find that NSILA-s is also a potent competitive inhibitor of the insulin-degrading system of the liver plasma membrane. The most purified NSILA-s preparation tested was 20-fold more potent than insulin itself, and significant inhibition of insulin degradation occurred at concentrations of NSILA-s similar to those found in plasma.Keywords
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