BLOCKAGE OF AMYLOID INDUCTION BY COLCHICINE IN AN ANIMAL MODEL
Open Access
- 1 October 1974
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 140 (4), 1102-1107
- https://doi.org/10.1084/jem.140.4.1102
Abstract
Colchicine was found to have a strong inhibitory effect on amyloid induction in an animal model. When CBA/J mice were treated with colchicine concurrently with the amyloid induction regimen, the incidence of amyloidosis was, depending upon the dosage of colchicine, significantly decreased (0.005–0.010 mg colchicine per day) or completely blocked (more than 0.015 mg colchicine per day). The colchicine treatment was effective not only when colchicine was given for the entire course of the amyloid induction regimen but also when it was given only in the late pre-amyloid or the amyloid phase of the regimen or to the recipients after the transfer of amyloid. The data suggest the colchicine is effective in blocking amyloidogenesis at its final stage(s), while it may not affect significantly amyloid already deposited in the tissue.Keywords
This publication has 10 references indexed in Scilit:
- Colchicine inhibition of casein-induced amyloidosis in mice.1974
- Amyloidosis and immunoglobulins.1974
- An analysis of the close relationship of lysosomes to early deposits of amyloid. Ultrastructural evidence in experimental mouse amyloidosis.1973
- THE MECHANISM OF ACTION OF COLCHICINEThe Journal of cell biology, 1973
- MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM HUMAN LEUKOCYTESThe Journal of cell biology, 1973
- Animal model for human disease: spontaneous and induced amyloidosis.1972
- Current Concepts of AmyloidAdvances in Immunology, 1972
- AmyloidosisNew England Journal of Medicine, 1967
- PATHOGENESIS OF AMYLOIDOSISActa Pathologica Microbiologica Scandinavica, 1964
- Studies in Experimental AmyloidosisArchives of Internal Medicine, 1962