Biochemical Evidence for Keratinization by Mouse Epidermal Cells in Culture
- 30 June 1978
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4349), 1491-1493
- https://doi.org/10.1126/science.566466
Abstract
More than 70 percent of the urea-extractable proteins from mouse stratum corneum or from differentiated cells of mouse epidermis grown in culture are two proteins of molecular weight 68,000 (keratin I) and 60,000 (kerae are two proteins of molecular weight 68,000 (keratin 1) and 60,000 (keratin 2), which are present in equimolar amounts on polyacrylamide gels. These proteins are the subunits of the keratin filaments, because when isolated from stratum corneum or cells grown in culture they form native-type epidermal keratin filaments in vitro. These observations provide biochemical evidence that epidermal cells grown in culture synthesize the major differentiation products of the epidermis.This publication has 11 references indexed in Scilit:
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