Evaluation of some pharmacological activities of Budmunchiamine - A isolated from Albizia amara
Open Access
- 1 May 2015
- journal article
- research article
- Published by FapUNIFESP (SciELO) in Brazilian Journal of Microbiology
- Vol. 46 (1), 139-143
- https://doi.org/10.1590/S1517-838246120131137
Abstract
The present investigations were aimed to evaluate the antimicrobial and antioxidant efficacies of budmunchiamine-A (BUA) of Albizia amara. The activity-guided isolation leaded to isolate the bioactive compound budmunchiamine-A from alkaloid extract of A. amara. The budmunchiamine-A showed significant broad-spectrum antimicrobial activity with zone of inhibition (ZOI), minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) values varied from 7.3 to 24.5 mm, 0.95 to 62.5 μg/mL, and 1.9 to 250 μg/mL, respectively. The budmunchiamine-A exhibited moderate antioxidant activity with inhibitory concentration 50% (IC50) value of 400 μg/mL in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and percent inhibition of β-carotene/linoleic acid was 67.8%. The results suggest the possible use of budmunchiamine-A as a molecular entity for drug development in pharmaceutical industry.Keywords
This publication has 5 references indexed in Scilit:
- Chemical composition, antimicrobial and antioxidant activities of the essential oil and the ethanol extract of Cleistocalyx operculatus (Roxb.) Merr and Perry budsFood and Chemical Toxicology, 2008
- Antimicrobial Activity of Some Medicinal Plants Used by Herbalists in Eastern Province, KenyaAfrican Journal of Traditional, Complementary and Alternative Medicines, 2008
- Evaluation of biological activity of crude extracts from plants used in Yucatecan Traditional Medicine Part I. Antioxidant, antimicrobial and β-glucosidase inhibition activitiesPhytomedicine, 2001
- Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogensJournal of Ethnopharmacology, 2001
- Biological Activity of Novel Macrocyclic Alkaloids (Budmunchiamines) from Albizia amara Detected on the Basis of Interaction with DNAJournal of Natural Products, 1991