The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses
- 15 May 2011
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 85 (10), 5208-5212
- https://doi.org/10.1128/jvi.02178-10
Abstract
Cytomegaloviruses (CMV) utilize a variety of immunomodulatory strategies to facilitate the establishment of lifelong persistence in their infected hosts. We show that the mouse CMV (MCMV) m155 open reading frame (ORF) is required for the posttranscriptional inhibition of CD40 expression in infected antigen-presenting cells. Consistent with the known importance of CD40-mediated costimulation of T cells, a m155-deficient virus induces enhanced MCMV epitope-specific CD4 T cell responses.This publication has 48 references indexed in Scilit:
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