Expanding horizons for receptors coupled to G proteins: diversity and disease
- 30 April 1994
- journal article
- review article
- Published by Elsevier BV in Current Opinion in Cell Biology
- Vol. 6 (2), 191-197
- https://doi.org/10.1016/0955-0674(94)90135-x
Abstract
The known repertoire of seven transmembrane domain receptors coupled to G proteins has expanded in several interesting directions. Both loss-of-function and activating mutations have been found at the root of a variety of diseases. More will undoubtedly be uncovered. The diversity of ligands which trigger G protein coupled receptors continues to grow, and with it the variety of known strategies for ligand detection. These and other developments promise continued excitement in this field.Keywords
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