Blood Pressure Components and End-stage Renal Disease in Persons With Chronic Kidney Disease

Abstract

Treatment of high blood pressure (BP) is one of the foundations of therapy to slow the progression from chronic kidney disease (CKD) to end-stage renal disease (ESRD).¹ A graded association between higher BP levels and ESRD risk has been shown in observational studies of persons with and without CKD.^2,3 Findings from some, but not all, clinical trials of persons with established CKD have suggested that lower BP levels are associated with slower progression of CKD among persons with proteinuria.^4,5 Based on these data, a BP goal of less than 130/80 mm Hg (rather than 1 However, the most recent evidence in support of this lower target has been conflicting.^6-8 The association of BP levels and ESRD risk among persons with established CKD has not been well studied in recent large, national, diverse, community-based settings.