Barrett's Esophagus
- 1 January 1997
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Annals of Surgery
- Vol. 225 (1), 17-30
- https://doi.org/10.1097/00000658-199701000-00003
Abstract
The authors provide an updated review the molecular biology of the p53 tumor suppressor gene with reference to its role in the malignant degeneration of Barrett's esophagus. Appreciation of the function of the tumor suppressor gene p53 has given new insight into regulation of the cell cycle, and the gene appears to play an important role in many solid tumors. Esophageal adenocarcinoma is increasing in frequency in the western world at an alarming rate and is unique because there is a clear metaplasia (Barrett's mucosa)/dysplasia/carcinoma sequence. p53 malfunction arises as an early event in this carcinogenic process and has been demonstrated in patients with nondysplastic Barrett's metaplasia. The possible causes of p53 malfunction in this setting are discussed. The most reliable method for the detection of p53 mutations is DNA sequencing. p53 immunohistochemistry appears too insensitive to act as a reliable marker for the presence of a mutation and cannot be used as a reliable marker for the future development of cancer. High-grade dysplasia within Barrett's mucosa remains the best clinical predictor of adenocarcinoma. The mutational spectrum observed in these tumors should provide clues to their etiology.Keywords
This publication has 88 references indexed in Scilit:
- Ambulatory oesophageal bile reflux monitoring in Barrett's oesophagusBritish Journal of Surgery, 1995
- Tumor suppressor p53 is a direct transcriptional activator of the human bax geneCell, 1995
- Expression of p53 protein in oesophageal carcinoma: Clinicopathological correlation and prognostic significanceBritish Journal of Surgery, 1994
- Potential application of p53 as an intermediate biomarker in Barrett's esophagusThe Annals of Thoracic Surgery, 1994
- G→A mutations in p53 and Ha‐ras genes in esophageal papillomas induced by N‐nitrosomethylbenzylamine in two strains of ratsMolecular Carcinogenesis, 1994
- Mutagenicity of nitric oxide is not caused by deamination of cytosine or 5-methylcytosine in double-stranded DNACarcinogenesis: Integrative Cancer Research, 1994
- p53 Sweeps Through Cancer ResearchScience, 1993
- Clinical Implications of the p53 Tumor-Suppressor GeneNew England Journal of Medicine, 1993
- The role of smoking and alcohol in metaplasia and cancer risk in Barrett's columnar lined oesophagus.Gut, 1993
- EditorialJournal of Clinical Gastroenterology, 1989