The Roles of Integrin α5β1 in Human Cancer
Open Access
- 1 December 2020
- journal article
- review article
- Published by Taylor & Francis Ltd in OncoTargets and Therapy
- Vol. ume 13, 13329-13344
- https://doi.org/10.2147/ott.s273803
Abstract
Cell adhesion to the extracellular matrix has important roles in tissue integrity and human health. Integrins are heterodimeric cell surface receptors that are composed by two non-covalently linked alpha and beta subunits that mainly participate in the interaction of cell-cell adhesion and cell-extracellular matrix and regulate cell motility, adhesion, differentiation, migration, proliferation, etc. In mammals, there have been eighteen α subunits and 8 β subunits and so far 24 distinct types of αβ integrin heterodimers have been identified in humans. Integrin α 5β 1, also known as the fibronectin receptor, is a heterodimer with α 5 and β 1 subunits and has emerged as an essential mediator in many human carcinomas. Integrin α 5β 1 alteration is closely linked to the progression of several types of human cancers, including cell proliferation, angiogenesis, tumor metastasis, and cancerogenesis. In this review, we will introduce the functions of integrin α 5β 1 in cancer progression and also explore its regulatory mechanisms. Additionally, the potential clinical applications as a target for cancer imaging and therapy are discussed. Collectively, the information reviewed here may increase the understanding of integrin α 5β 1 as a potential therapeutic target for cancer.Keywords
This publication has 183 references indexed in Scilit:
- Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid TumorsCancers, 2013
- Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasisOncogene, 2010
- IntegrinsCell and tissue research, 2009
- Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasionBritish Journal of Cancer, 2009
- N-Glycosylation of the I-like Domain of β1 Integrin Is Essential for β1 Integrin Expression and Biological FunctionOnline Journal of Public Health Informatics, 2009
- Integrins in angiogenesis and lymphangiogenesisNature Reviews Cancer, 2008
- Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motilityOncogene, 2007
- Angiogenesis in life, disease and medicineNature, 2005
- Integrin signalling during tumour progressionNature Reviews Molecular Cell Biology, 2004
- Integrins: Bidirectional, Allosteric Signaling MachinesCell, 2002