P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma
Open Access
- 5 December 1991
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 325 (23), 1608-1614
- https://doi.org/10.1056/nejm199112053252304
Abstract
Multidrug resistance in chemotherapy for cancer is characterized by increased genetic expression of P-glycoprotein, which acts as an ATP-dependent drug-efflux pump. To determine whether P-glycoprotein levels are of prognostic value in such cases, we measured these levels immunohistochemically in a retrospective study of sequential tumor samples from 67 children with neuroblastoma.Keywords
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