Heavy Phenacetin Use and Bladder Cancer in Women Aged 20 to 49 Years
- 1 August 1985
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 313 (5), 292-295
- https://doi.org/10.1056/nejm198508013130504
Abstract
We investigated the use of analgesics containing phenacetin or acetaminophen in 173 young women with urinary bladder cancer and 173 matched controls. The cases, who were 20 to 49 years old at the time of diagnosis of cancer, were 6.5 times more likely to report regular use of analgesics containing phenacetin at least one year before diagnosis than were their matched controls (odds ratio, 6.5; 95 per cent confidence interval, 1.5 to 59.2). Among the 15 women (13 cases and 2 controls) reporting regular use of phenacetin-containing drugs, 8 of the cases and 1 of the controls reported daily use for over one year (P = 0.04). Excessive use of analgesics containing acetaminophen was not reported. The increased risk of bladder cancer in young women who regularly used phenacetin-containing products remained present after adjustments for all other identified risk factors. (N Engl J Med 1985; 313:292–5.)Keywords
This publication has 11 references indexed in Scilit:
- Analgesics and Tobacco as Risk Factors for Cancer of the Ureter and Renal PelvisJournal of Urology, 1983
- Phenacetin‐Containing Analgesics and Cancer of the Bladder or Renal Pelvis in WomenBritish Journal of Urology, 1983
- Epidemiologic Study of Abuse of Analgesics Containing PhenacetinNew England Journal of Medicine, 1983
- Analgesics and cancer of the renal pelvis in New South WalesCancer, 1982
- Analgesic NephropathyDrugs, 1982
- Urinary Tract Carcinoma in Patients with Analgesic NephropathyNephron, 1981
- Phenacetin abuse related to bladder cancerEnvironmental Research, 1979
- Sampling Methods for Random Digit DialingJournal of the American Statistical Association, 1978
- Analgesic Abuse, Renal Parenchymal Disease and Carcinoma of the Kidney or UreterAustralian and New Zealand Journal of Medicine, 1977
- Transitional Cell Tumors of the Renal Pelvis in Analgesic AbusersScandinavian Journal of Urology and Nephrology, 1968