Serum lipid, lipoprotein and apolipoprotein changes in gestational diabetes mellitus: a cross-sectional and prospective study.
Open Access
- 1 August 1996
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 49 (8), 634-637
- https://doi.org/10.1136/jcp.49.8.634
Abstract
AIMS: To compare serum lipid, lipoprotein and apolipoprotein concentrations during and six to 12 months after pregnancy in control and diabetic women. METHODS: The serum lipid, lipoprotein and apolipoprotein concentrations were measured in 20 women with gestational diabetes mellitus (GDM) and 22 women with normal glucose tolerance (controls) during the third trimester of pregnancy and six to 12 months after delivery. RESULTS: During pregnancy the women with GDM had higher serum triglyceride (mean (95% confidence interval (CI)), 2.91 (2.22-3.51) v 2.1 (1.75-2.52)) but lower low density lipoprotein (LDL) cholesterol concentrations compared with controls (mean (SD), 3.08 (1.2) v 4.01 (1.1). Total cholesterol, high density lipoprotein (HDL) cholesterol and apolipoprotein concentrations were not significantly different between the two groups. After pregnancy, total cholesterol, HDL cholesterol, triglyceride, and apolipoprotein A1 and B decreased in a parallel manner, resulting in lower concentrations, comparable between the two groups. LDL cholesterol concentrations decreased after pregnancy in the controls (mean (SD), 4.01 (1.1) v 2.69 (0.6)) but not in those with GDM (3.08 (1.2) v 2.72 (0.7)). The change in lipid concentrations was not related to change in weight. CONCLUSION: Development of diabetes during pregnancy induces a state of dyslipidaemia characterised by elevated triglyceride concentrations, as seen in other insulin resistance states. However, GDM seems to blunt the increase in LDL cholesterol during pregnancy and this requires further investigation. Whether the changes in lipoprotein metabolism in GDM are significant for the health status of the mother and the foetus requires further study.This publication has 28 references indexed in Scilit:
- Ethnic differences in lipid and lipoprotein metabolism in pregnant women of African and Caucasian origin.Journal of Clinical Pathology, 1994
- Serum lipids, lipoproteins and apolipoproteins in pregnant non-diabetic patients.Journal of Clinical Pathology, 1994
- Hypertriglyceridemia during late pregnancy is associated with the formation of small dense low-density lipoproteins and the presence of large buoyant high-density lipoproteinsMetabolism, 1994
- Sex hormones and lipoprotein metabolismCurrent Opinion in Lipidology, 1994
- Calculated Low-Density Lipoprotein Cholesterol Should Not Be Used for Management of Lipoprotein Abnormalities in Patients With Diabetes MellitusDiabetes Care, 1993
- Number of Pregnancies and the Subsequent Risk of Cardiovascular DiseaseThe New England Journal of Medicine, 1993
- Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity.Circulation, 1992
- Longitudinal Study of Plasma Lipids and Lipoprotein Cholesterol in Normal Pregnancy and PuerperiumGynecologic and Obstetric Investigation, 1988
- Effect of gender, age, and lipid status on low density lipoprotein subfraction distribution. Results from the Framingham Offspring Study.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1987
- Relationships of Lipoprotein Lipids to Mild Fasting Hyperglycemia and Diabetes in PregnancyDiabetes Care, 1980