Nesidioblastosis Coexisting With Islet Cell Tumor and Intraductal Papillary Mucinous Hyperplasia
Open Access
- 1 October 2001
- journal article
- Published by Archives of Pathology and Laboratory Medicine in Archives of Pathology & Laboratory Medicine
- Vol. 125 (10), 1344-1347
- https://doi.org/10.5858/2001-125-1344-ncwict
Abstract
A coexisting of intraductal papillary mucinous hyperplasia (IPMH) and islet cell tumor with nesidioblastosis of the pancreas in a 51-year-old man is reported. All of the clinical data indicated an insulinoma. A distal pancreatectomy was performed. A discrete mass measuring 1.9 × 2.0 cm was grossly identified in the tail of the pancreas. There were no other gross lesions. An islet cell tumor with nesidioblastosis was confirmed by immunostains and ultrastructural study. In addition, an IPMH was found that involved mainly branches of the pancreatic duct. The islet cell tumor and IPMH were topographically separated; however, there was a histologically intimate relationship between the nesidioblastosis and the IPMH. These findings indicate that the IPMH may have derived from autocrine and paracrine influences on the existing duct epithelial cells. To the best of our knowledge, this is the first report of nesidioblastosis coexisting with islet cell tumor and IPMH.Keywords
This publication has 7 references indexed in Scilit:
- Genetic Progression and Divergence in Pancreatic CarcinomaThe American Journal of Pathology, 2000
- Mixed Ductal-Endocrine Carcinoma of the PancreasArchives of Pathology & Laboratory Medicine, 2000
- Intraductal papillary mucinous tumors of the pancreasThe American Journal of Surgery, 1999
- Endocrine cells in intraductal papillary-mucinous neoplasms of the pancreasVirchows Archiv, 1997
- Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patientsVirchows Archiv, 1994
- An immunohistochemical study of the c-erbB-2 oncogene product in intraductal mucin-hypersecreting neoplasms and in ductal cell carcinomas of the pancreasCancer, 1993
- Nesidioblastosis, Islet Cell Hyperplasia, and Adenomatosis in a Case of Metastasizing Insulinoma: Contribution to the Genesis of the Islets of LangerhansDiabetes Care, 1980