A study of the comparative efficacy of three common analgeisics in the control of pain after third molar surgery under local anaesthesia
- 1 December 2002
- journal article
- Published by Wiley in Australian Dental Journal
- Vol. 47 (4), 327-330
- https://doi.org/10.1111/j.1834-7819.2002.tb00546.x
Abstract
The aim of this study was to evaluate the comparative efficacy of three commonly used analgesics (Panadeine, Diflunisal and Etodolac) in the control of pain after third molar surgery under local anaesthesia. A randomized control study. Outcome of primary efficacy was judged by overall assessment of the area under the curve of graphs for pain intensity, measured from serial visual analogue scales over a 24-hour period. Other measures of efficacy included the number (per cent) of patients who took 'additional' analgesics and the incidence of adverse effects occurring in each treatment group over the study period. The three drugs were effective in the control of post-operative pain (p<0.01). Variations in pain intensity and the use of additional medication between the treatment groups were observed over the study period. The Diflunisal group experienced less pain than the Panadeine or Etodolac group (p<0.01). Furthermore, a lesser number of those in the Diflunisal group used additional medication compared to the other two groups (p<0.01). The incidence of side effects from all three drugs was low. Diflunisal is superior in the control of pain following third molar surgery under local anaesthesia than either Panadeine or Etodolac, and has few side effects.Keywords
This publication has 16 references indexed in Scilit:
- Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic reviewBMJ, 1996
- A double-blind placebo-controlled study to assess the efficacy of a compound analgesic to prevent postoperative pain following oral surgeryBritish Dental Journal, 1996
- A study of the comparative efficacy of four common analgesics in the control of postsurgical dental painOral Surgery, Oral Medicine, Oral Pathology, 1990
- Factors affecting the onset and severity of pain following the surgical removal of unilateral impacted mandibular third molar teethBritish Dental Journal, 1988
- Paracetamol and diflunisal for pain relief following third molar surgery in Hong Kong ChineseInternational Journal of Oral & Maxillofacial Surgery, 1987
- Double-blind evaluation of etodolac (200 mg, 400 mg) compared with zomepirac (100 mg) and placebo on third molar extraction painOral Surgery, Oral Medicine, Oral Pathology, 1986
- Comparison of etodolac, zomepirac, and placebo for relief of pain after oral surgeryJournal of Oral and Maxillofacial Surgery, 1986
- An investigation into post-operative pain after third molar surgery under local analgesiaBritish Journal of Oral and Maxillofacial Surgery, 1985
- The effectiveness of 100 and 200 mg etodolac (Ultradol), aspirin, and placebo in patients with pain following oral surgeryOral Surgery, Oral Medicine, Oral Pathology, 1983
- Pain control in dentistryBritish Dental Journal, 1980