A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-dimethylaminocyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds

Abstract

A series of new nontricyclic antidepressant compounds was synthesized. A representative of this class is compound 6. Five structural parameters were investigated: ring size, cis/trans stereochemistry, amide substitution, aromatic substitution and amine substitution. The pharmacological tests employed, indicative of antidepressant activity, were yohimbine potentiation test, oxotremorine antagonism test and apomorphine potentiation test. Structure-activity relationship is discussed. Mice were used in this study.