Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells
- 1 May 1981
- journal article
- research article
- Published by Springer Science and Business Media LLC in Inflammation Research
- Vol. 11 (3), 184-192
- https://doi.org/10.1007/bf01967612
Abstract
Oxatomide inhibits the release of histamine from rat peritoneal mast cells in vitro induced by C 48/80, antigen, anti-IgE and ionophore A 23 187, without effect on non-specific release byn-decylamine. Its effect is concentration- and pH-dependent and decreases with increasing extracellular Ca2+-concentrations. Prolonged incubation does not enhance the inhibition, which is lost after one single wash-out. Aminophylline and isoproterenol are not potentiated by oxatomide. The present study points to an effect of oxatomide on a Ca2+-dependent process at the level of cell membrane common to antigen, C 48/80 and ionophore A 23 187.Keywords
This publication has 41 references indexed in Scilit:
- Oxatomide protects against degranulation of rat peritoneal mast cells during in vitro challenge with antigen or compound 48/80. Ultrastructural aspectsInflammation Research, 1981
- Oxatomide: Inhibition and stimulation of histamine release from human lung and leucocytes in vitroInflammation Research, 1980
- Inhibition and stimulation of histamine release by oxatomideInternational Journal of Immunopharmacology, 1979
- Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazineInflammation Research, 1979
- Oxatomide protectsTrichinella spiralis infected mice from lethal anaphylaxisInflammation Research, 1978
- Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediatorsCellular and Molecular Life Sciences, 1977
- Inhibition of adenosine-3′, 5′-cyclic monophosphate phosphodiesterase by potential antiallergic compoundsLife Sciences, 1976
- Inositol phospholipids and cell surface receptor functionBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1975
- The effect of disodium cromoglycate on the release of histamine and degranulation of rat mast cells induced by compound 4880Life Sciences, 1971
- MECHANISMS OF IMMUNOLOGIC INJURY OF RAT PERITONEAL MAST CELLSThe Journal of Experimental Medicine, 1966