Kidney biopsy findings in primary Sjögren syndrome
Open Access
- 27 March 2015
- journal article
- research article
- Published by Oxford University Press (OUP) in Nephrology Dialysis Transplantation
- Vol. 30 (8), 1363-1369
- https://doi.org/10.1093/ndt/gfv042
Abstract
Renal involvement is rare in primary Sjögren syndrome (PSS). In this study, we examined renal biopsy findings in patients with PSS and correlated them with their clinical and renal findings. Twenty-five patients with PSS who underwent renal biopsies from two renal units in Scotland between 1978 and 2013 were identified from renal biopsy database. We examined the renal morphologic, clinical and renal findings at the time of renal biopsy, renal and patient outcomes. The diagnosis of PSS preceded renal biopsy in 18/25 patients. In this group, the median duration of the disease was 5.5 years. Significant proteinuria, combined microscopic haematuria and proteinuria and reduced renal excretory function were found in 76, 56 and 84% of patients, respectively. The 3-year actuarial patient survival was significantly lower in patients with glomerulonephritis as compared with tubulointerstitial nephritis (66 versus 100%, P = 0.02). There was no difference in 3-year actuarial renal survival between these two groups (92 versus 92%, P = 1.0). Renal biopsy is rare in PSS and often reveals diverse pathological findings. Glomerulonephritis, as compared with tubulointerstitial nephritis, is associated with higher early mortality. Further studies are needed to evaluate the utility of renal biopsy and its impact on disease management.This publication has 16 references indexed in Scilit:
- Clinically Significant Renal Involvement in Primary Sjögren's Syndrome: Clinical Presentation and OutcomeArthritis & Rheumatism, 2013
- Renal Involvement in Primary Sjögren's SyndromeClinical Journal of the American Society of Nephrology, 2009
- Membraneous Glomerulonephritis and Non-Hodgkin's Lymphoma in a Patient with Primary Sjoegren's SyndromeInternal Medicine, 2007
- Primary Sjogren's syndrome: new clinical and therapeutic conceptsAnnals Of The Rheumatic Diseases, 2004
- Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus GroupAnnals Of The Rheumatic Diseases, 2002
- Clinical and morphological features of kidney involvement in primary Sjögren's syndromeNephrology Dialysis Transplantation, 2001
- Clinically Significant and Biopsy-Documented Renal Involvement in Primary Sjogren SyndromeMedicine, 2000
- Clinical evolution, and morbidity and mortalityof primary Sjögren's syndromeSeminars in Arthritis and Rheumatism, 2000
- Sjogren's syndrome complicated by MPO-ANCA positive crescentic glomerulonephritisNephrology Dialysis Transplantation, 1999
- Membranoproliferative Glomerulonephritis in a Patient with Primary Sjogren’s SyndromeAmerican Journal of Nephrology, 1988