Pancreatic Endocrine Tumors Less Than 4 cm in Diameter
- 1 August 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pancreas
- Vol. 39 (6), 825-828
- https://doi.org/10.1097/mpa.0b013e3181cf155c
Abstract
Pancreatic endocrine tumors (PETs) are usually small, benign or low-grade malignant, and surgery should preserve the pancreatic parenchyma as much as possible. The aim of the study was to evaluate the postoperative and long-term survival of patients undergoing enucleation in small PETs.Of 82 patients having PETs, 46 with tumor less than 4 cm in diameter, without distant metastases and with R0 resection by final pathologic examination, were included in this study. Enucleation was performed when the tumor did not involve the main pancreatic duct and in the absence of peripancreatic lymphadenopathy (group A); a typical resection was carried out in all other cases (group B). The 2 groups were compared regarding postoperative mortality and morbidity, pancreatic fistula, postoperative hospital stay, reoperation, World Health Organization classification, TNM stage, recurrence, and long-term survival.There were 15 patients (32.6%) in group A and 31 (67.4%) in group B. Postoperative and long-term results were similar in the 2 groups, whereas World Health Organization classification was significantly different; enucleation was performed more frequently than typical R0 resection in benign tumors (P = 0.009).Enucleation should be reserved for patients having benign PETs less than 4 cm in diameter and far from the main pancreatic duct.Keywords
This publication has 10 references indexed in Scilit:
- Value of Both WHO and TNM Classification Systems for Patients with Pancreatic Endocrine Tumors: Results of a Single‐Center SeriesWorld Journal of Surgery, 2009
- Small Pancreatic and Periampullary Neuroendocrine Tumors: Resect or Enucleate?Journal of Gastrointestinal Surgery, 2009
- Prognostic Score Predicting Survival After Resection of Pancreatic Neuroendocrine TumorsAnnals of Surgery, 2008
- Effect of hospital volume on outcome of pancreaticoduodenectomy in ItalyBritish Journal of Surgery, 2007
- Clinicopathologic Features and Treatment Trends of Pancreatic Neuroendocrine Tumors: Analysis of 9,821 PatientsJournal of Gastrointestinal Surgery, 2007
- Prognostic Factors in Periampullary and Pancreatic Tumor Resection in Elderly PatientsWorld Journal of Surgery, 2006
- Endocrine pancreatic tumors: factors correlated with survivalAnnals of Oncology, 2005
- Postoperative pancreatic fistula: An international study group (ISGPF) definitionSurgery, 2005
- Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumoursGut, 2005
- Nonfunctioning pancreatic endocrine tumors: a multicenter clinical studyThe American Journal of Gastroenterology, 2003