Evaluation of Stereotactic Body Radiation Therapy in the Management of Adrenal Metastases from Non-Small Cell Lung Cancer
- 1 January 2015
- journal article
- Published by SAGE Publications in Tumori Journal
- Vol. 101 (1), 98-103
- https://doi.org/10.5301/tj.5000222
Abstract
Aims and Background In this retrospective analysis, we evaluated the use of stereotactic body radiation therapy in the management of adrenal metastases from non-small cell lung cancer and report our single center experience. Methods and Study design Fifteen non-small cell lung cancer patients (9 male, 6 female) with 17 adrenal metastases referred to Gulhane Military Medical Academy Radiation Oncology Department were treated using active breathing control-guided stereotactic body radiation therapy between December 2009 and October 2013. Dose per fraction was 10 Gy to deliver a total dose of 30 Gy over 3 consecutive days for all metastatic adrenal lesions. The mean gross tumor volume was 28.4 cc (range 6.6-101.5) and mean planning target volume was 57.4 cc (range 16.5-143.8). Results At a median follow-up of 16 months, local control was 86.7% and overall survival was 33.3%. Median disease-free survival was 10 months. Treatment response according to RECIST was categorized as complete response in 3 patients (20%), partial response in 5 patients (33.3%), stable disease in 5 patients (33.3%), and progressive disease in 2 patients (13.3%). Most common acute toxicity was grade 1 nausea (n = 7) and grade 1 fatigue (n = 12). There was no case of grade ≥3 acute or late toxicity. Conclusions Stereotactic body radiation therapy offers a safe and efficacious management strategy for adrenal metastases from non-small cell lung cancer by providing excellent local control with negligible treatment related toxicity.Keywords
This publication has 39 references indexed in Scilit:
- Adrenalectomy for solid tumor metastases: Results of a multicenter European studySurgery, 2013
- Is there an oligometastatic state in non-small cell lung cancer? A systematic review of the literatureLung Cancer, 2013
- Adrenalectomy Improves Outcomes of Selected Patients with Metastatic CarcinomaWorld Journal of Surgery, 2012
- Outcomes of Adrenalectomy for Isolated Synchronous Versus Metachronous Adrenal Metastases in Non–Small-Cell Lung Cancer: A Systematic Review and Pooled AnalysisJournal of Clinical Oncology, 2008
- Surgical treatment of solitary adrenal metastasis from non-small cell lung cancerThe Journal of Thoracic and Cardiovascular Surgery, 2005
- Metastatic tumours of the adrenal glands: a 30‐year experience in a teaching hospitalClinical Endocrinology, 2002
- Resection of adrenal metastases from non-small cell lung cancer: a multicenter studyThe Annals of Thoracic Surgery, 2001
- The role of surgery in the treatment of clinically isolated adrenal metastasisCancer, 1998
- Does Resection of Adrenal Metastases From Non-Small Cell Lung Cancer Improve Survival?The Annals of Thoracic Surgery, 1996
- Metastases in carcinoma.Analysis of 1000 autopsied casesCancer, 1950