Prediction of compensated liver cirrhosis by ultrasonography and routine blood tests in patients with chronic viral hepatitis
Open Access
- 1 January 2010
- journal article
- Published by The Korean Association for the Study of the Liver in The Korean Journal of Hepatology
- Vol. 16 (4), 369-375
- https://doi.org/10.3350/kjhep.2010.16.4.369
Abstract
Liver biopsy is a standard method for diagnosis of liver cirrhosis in patients with chronic hepatitis. Because liver biopsy is an invasive method, non-invasive methods have been used for diagnosis of compensated liver cirrhosis in patients with chronic hepatitis. The current study was designed to evaluate the usefulness of ultrasonography and routine blood tests for diagnosis of compensated liver cirrhosis in patients with chronic viral hepatitis. Two hundred three patients with chronic viral hepatitis who underwent liver biopsy were included in this study and ultrasonography and routine blood tests were analyzed retrospectively. Ultrasonographic findings, including surface nodularity, parenchyma echogenecity, and spleen size, were evaluated. The diagnostic accuracy of ultrasonography and routine blood tests were examined. Discriminant analysis with forward stepwise selection of variables showed that liver surface nodularity, platelet count, and albumin level were independently associated with compensated liver cirrhosis (p95% specificity: platelet count 1.3; and surface nodularity. If at least one of the four variables exists in a patient with chronic viral hepatitis, we can predict liver cirrhosis with 90% specificity and 61% sensitivity. These results suggest that four variables (platelet count 1.3, and surface nodularity) can be used for identification of liver cirrhosis in patients with chronic viral hepatitis with high specificity.Keywords
This publication has 30 references indexed in Scilit:
- National Institutes of Health consensus development conference statement: Management of hepatitis BHepatology, 2009
- Non-invasive assessment of liver fibrosis in chronic liver diseases: Implementation in clinical practice and decisional algorithmsWorld Journal of Gastroenterology, 2009
- Model consisting of ultrasonographic and simple blood indexes accurately identify compensated hepatitis B cirrhosisJournal of Gastroenterology and Hepatology, 2008
- Diagnosis of liver fibrosis by transient elastography (FibroScan) and non‐invasive methods in Crohn's disease patients treated with methotrexateAlimentary Pharmacology & Therapeutics, 2006
- Sampling variability of liver fibrosis in chronic hepatitis CHepatology, 2003
- A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis CHepatology, 2003
- Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive modelHepatology, 2002
- Epidemiology of hepatitis CHepatology, 1997
- Hepatitis B: global importance and need for controlVaccine, 1990
- Complications following percutaneous liver biopsy: A multicentre retrospective study on 68 276 biopsiesJournal of Hepatology, 1986