A Phase I Study ofIn vitroExpanded Natural Killer T Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer
Open Access
- 15 October 2006
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 12 (20), 6079-6086
- https://doi.org/10.1158/1078-0432.ccr-06-0114
Abstract
Purpose: Human Vα24 natural killer T (Vα24 NKT) cells bearing an invariant Vα24JαQ antigen receptor are activated by a glicolipid ligand α-galactosylceramide (αGalCer; KRN7000) in a CD1d-dependent manner. The human Vα24 NKT cells activated with αGalCer and interleukin-2 have been shown to produce large amounts of cytokines, such as IFN-γ, and also exerting a potent killing activity against various tumor cell lines. We did a phase I study with autologous activated Vα24 NKT cell therapy.Keywords
This publication has 37 references indexed in Scilit:
- Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patientsThe Journal of Experimental Medicine, 2005
- Peripheral blood IFN‐γ‐secreting Vα24+Vβ11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor loadInternational Journal of Cancer, 2005
- CD1: Antigen Presentation and T Cell FunctionAnnual Review of Immunology, 2004
- Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell‐mediated expansionInternational Journal of Cancer, 2004
- The Regulatory Role of Vα14 NKT Cells in Innate and Acquired Immune ResponseAnnual Review of Immunology, 2003
- Sequential production of interferon-γ by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramideBlood, 2002
- Selective induction of NK cell proliferation and cytotoxicity by activated NKT cellsEuropean Journal of Immunology, 2000
- THE CD1 SYSTEM: Antigen-Presenting Molecules for T Cell Recognition of Lipids and GlycolipidsAnnual Review of Immunology, 1999
- MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and FunctionAnnual Review of Immunology, 1997
- Metastatic pattern in adenocarcinoma of the lung: An autopsy study from a cohort of 137 consecutive patients with complete resectionThe Journal of Thoracic and Cardiovascular Surgery, 1995