Reference to textbooks on pediatrics and neurology, individual case reports and review articles on multiple sclerosis showed that multiple sclerosis can occur in childhood in typical form and has been occasionally confirmed by necropsy. During the past year 3 children were seen at the Neurological Institute in New York in whom the diagnosis of multiple sclerosis seemed reasonably certain. Four additional patients are presented in whom that diagnosis was suspected. In the latter group years of observation will be required for confirmation of the diagnosis.