The significance of Mg in prebiotic geochemistry
Open Access
- 20 March 2012
- journal article
- Published by Wiley in Geobiology
- Vol. 10 (4), 269-279
- https://doi.org/10.1111/j.1472-4669.2012.00323.x
Abstract
Magnesium plays a special role in biochemistry because of its ability to coordinate six oxygen atoms efficiently in its first coordination shell. Such oxygen atoms may be part of one or two charged oxyanions, which means that Mg2+ can, for instance, tie together two different phosphate groups that are located at distance from each other in a macromolecule, and in this way be responsible for the folding of molecules like RNA. This property of Mg2+ also helps the stabilization of diphosphate and triphosphate groups of nucleotides, as well as promoting the condensation of orthophosphate to oligophosphates, like pyrophosphate and trimetaphosphate. Borates, on the other hand, are known to promote the formation of nucleobases and carbohydrates, ribose in particular, which is yet another constituent of nucleotides. The oldest borate minerals that we find on Earth today are magnesium borates. Dissolved borate stabilizes pentose sugars by forming complexes with cis-hydroxyl groups. In the furanose form of ribose, the preferential binding occurs to the 2 and 3 carbon, leaving the 5 carbon free for phosphorylation. The central role of Mg2+ in the function of ribozymes and its ‘archaic’ position in ribosomes, and the fact that magnesium generally has coordination properties different from other cations, suggests that the inorganic chemistry of magnesium had a key position in the first chemical processes leading to the origin and early evolution of life.Keywords
This publication has 100 references indexed in Scilit:
- Early Archean serpentine mud volcanoes at Isua, Greenland, as a niche for early lifeProceedings of the National Academy of Sciences of the United States of America, 2011
- Na+-translocating Membrane Pyrophosphatases Are Widespread in the Microbial World and Evolutionarily Precede H+-translocating PyrophosphatasesOnline Journal of Public Health Informatics, 2011
- Links Between Hydrothermal Environments, Pyrophosphate, Na+, and Early EvolutionOrigins of Life and Evolution of Biospheres, 2011
- Bidentate RNA–magnesium clamps: On the origin of the special role of magnesium in RNA foldingRNA, 2010
- Reduction of nitrogen compounds in oceanic basement and its implications for HCN formation and abiotic organic synthesisGeochemical Transactions, 2009
- A recurrent magnesium-binding motif provides a framework for the ribosomal peptidyl transferase centerNucleic Acids Research, 2009
- Evolutionary primacy of sodium bioenergeticsBiology Direct, 2008
- Rethinking early Earth phosphorus geochemistryProceedings of the National Academy of Sciences of the United States of America, 2008
- Biological formation of ethane and propane in the deep marine subsurfaceProceedings of the National Academy of Sciences of the United States of America, 2006
- Phosphorus in prebiotic chemistryPhilosophical Transactions B, 2006