Propofol vs thiopentone as anaesthetic agents for short operative procedures
- 1 January 1987
- journal article
- clinical trial
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 31 (1), 63-66
- https://doi.org/10.1111/j.1399-6576.1987.tb02522.x
Abstract
In a randomized open study, 120 healthy female patients were included. For short gynaecological procedures they were anaesthetized with either propofol 2.5 mg X kg-1 (n = 60) or thiopentone 5 mg X kg-1 (n = 60) in combination with nitrous oxide/oxygen (67%/33%). Supplementary doses of propofol (10-20 mg) or thiopentone (25-50 mg) were given when necessary during the procedure. Induction characteristics for propofol and thiopentone 1 min after start of induction were similar. Propofol seemed to have a more depressant effect than thiopentone on the circulatory response to anaesthesia. Recovery times from the end of the operative procedure until the patients opened their eyes on command and were orientated were shorter in the propofol patients compared to the thiopentone patients. In the propofol group, patients recalled discomfort on injection more often than patients anaesthetized with thiopentone. Otherwise, the side-effects were similar in both groups. We conclude that propofol is similar to thiopentone in its anaesthetic qualities during induction and maintenance of short anaesthetic procedures. Propofol was associated with a more rapid emergence from anaesthesia than thiopentone.Keywords
This publication has 10 references indexed in Scilit:
- USE OF AN EMULSION OF ICI 35868 (PROPOFOL) FOR THE INDUCTION AND MAINTENANCE OF ANAESTHESIABritish Journal of Anaesthesia, 1985
- COMPARISION OF ICI 35868, ETOMIDATE AND METHOHEXITONE FOR DAY-CASE ANAESTHESIABritish Journal of Anaesthesia, 1985
- Dose requirements of ICI 35,868 (Propofol, ‘Diprivan’) in a new formulation for induction of anaesthesiaAnaesthesia, 1984
- HAEMODYNAMIC EFFECTS OF INFUSIONS OF DIISOPROPYL PHENOL (ICI 35 868) DURING NITROUS OXIDE ANAESTHESIA IN MANBritish Journal of Anaesthesia, 1983
- Acute cardiovascular changes following disoprofolAnaesthesia, 1982
- USE OF DI-ISOPROPYL PHENOL AS MAIN AGENT FOR SHORT PROCEDURESBritish Journal of Anaesthesia, 1981
- Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agentsJournal of Medicinal Chemistry, 1980
- PRELIMINARY EXPERIENCE WITH ICI 35 868 AS AN I.V. INDUCTION AGENT: COMPARISON WITH ALTHESINBritish Journal of Anaesthesia, 1980
- Suspected anaphylactic reaction to Cremophor EL.BMJ, 1980
- Arguments for Fisher's Permutation TestThe Annals of Statistics, 1975